FAQ

What is BPC-157 Peptide?

BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a naturally occurring protein found in human gastric juice. It is made up of 15 amino acids and has been widely studied in scientific research for its potential role in tissue repair, cellular protection, and regenerative processes.

In laboratory research, BPC-157 is often examined for its effects on cellular healing mechanisms, inflammation pathways, and tissue regeneration. Because of its stability and unique biological properties, it has become one of the most studied peptides in regenerative and experimental research fields.

How BPC-157 Works

Researchers believe BPC-157 may interact with several biological pathways involved in healing and cellular protection. Studies suggest that BPC-157 may influence processes such as angiogenesis (formation of new blood vessels), collagen production, and cellular signaling involved in tissue repair.

Because of these mechanisms, the peptide is frequently investigated in research focusing on recovery and regenerative biology.

Research Applications of BPC-157

BPC-157 is commonly studied in laboratory research related to:

  • Tissue regeneration and repair
  • Tendon and ligament recovery studies
  • Muscle healing research
  • Inflammation response pathways
  • Gastrointestinal tissue protection
  • Cellular growth and regeneration mechanisms

These areas of study have contributed to BPC-157 becoming one of the most recognized peptides in the field of experimental peptide research.

Key Characteristics of BPC-157

  • Synthetic peptide composed of 15 amino acids
  • Derived from a protective gastric protein fragment
  • Highly stable in laboratory environments
  • Frequently used in regenerative and biochemical research

BPC-157 in Peptide Research

Due to its unique biological profile, BPC-157 continues to be explored by researchers studying cellular repair processes, regenerative mechanisms, and protective biological pathways. Its potential ability to support tissue recovery and cellular signaling makes it an important compound in ongoing peptide research.

What is MOTS-c? 

MOTS-c is a 16 amino acid peptide that is coded by the mitochondrial genome. The mitochondria are the “power generators” in cells that convert chemical energy from food into a form that cells can use. Two other mitochondrial-derived peptides (MDPs) have also been discovered so far, humanin and SHLP1-6, but their possible involvement in human performance enhancement is unknown. According to new research, mitochondrial-derived peptides such as MOTS-c have a role in maintaining mitochondrial function and protecting cells under different stresses1.  It has been shown that exercise causes MOTS-c levels to go up in humans. Furthermore, it has been shown in mice that MOTS-c treatment improves physical performance in mice of all ages and seems to regulate skeletal muscle metabolism and gene expression1.  

Are there medical uses for MOTS-c? 

No, MOTS-c is still an experimental peptide being explored for therapeutic purposes related to aging and obesity. It is not approved by the Food and Drug Administration (FDA) for use in humans. The FDA has also clarified that it is one among many peptides or drugs that are unlawful to use in making compounded medications2. This means that compounding pharmacies (special pharmacies that can custom mix medications) are not supposed to make medications with MOTS-c. 

Is MOTs-c prohibited in sport? 

Yes, MOTS-c is prohibited at all times under Section 4.4 Metabolic Modulators, 4.4.1. Activators of the AMP-activated protein kinase (AMPK) on the World Anti-Doping Agency Prohibited List.   

Can athletes get a Therapeutic Use Exemption (TUE) for MOTS-c? 

No, athletes cannot get a TUE for MOTS-c because there is no approved therapeutic use for this experimental drug. 

Is MOTS-c used in dietary supplements? 

No, MOTS-c is not a legitimate dietary ingredient and cannot legally be used in dietary supplements.   

Is MOTS-c available online? 

Yes, there are many websites that advertise MOTS-c as an injectable weight loss and body building peptide drug for “for research purposes only.” However, just because it’s available for sale online doesn’t mean it is safe or legal. Currently it is very difficult for the FDA to regulate online sales of products that are sold “for research purposes only.” In many cases there are no direct laws that prohibit or support such sales. Despite this, there are many purported users on various social media platforms that claim to buy MOTS-c from online sellers and use it for losing weight or building muscle. Athletes are strongly encouraged NOT to purchase or use any product that is sold with this disclaimer. 

Is MOTS-c safe to use? 

Currently it is unknown under what conditions (if any) it is safe to use MOTS-c because there are no completed clinical trials. However, among people who claim to purchase MOTS-c online, there are many reported side effects, including increased heart rate or heart palpitations, injection site irritation, insomnia, and fever. There is also no data available on what happens with long-term use of MOTS-c. 

References 

  1. Reynolds, J. C. et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 12, 470, doi:10.1038/s41467-020-20790-0 (2021).